Heads 2.5 mi. NE of Tetlin Junction, flows E across Alaska-Canada boundary to White River in Yukon, Canada, Yukon-Tanana High.
From Yukon Place Names database: Names for prospector Joseph Ladue (1854-1901) who wintered in the Yukon 1884-85. Ladue came from Schuyler, NY and was a pre-Klondike Gold Rush miner and trader who founded Dawson City.