Extends NE-SW between Canyon Creek and Chikuminuk Lake on the south, and Tanana River on the north; bounded on the southeast by Kantishna River, North Fork Kuskokwim River, Kuskokwim River, Holitna River, and Kogrukluk River, and on northwest by the Kaiyuh Mountains at Sulatna Crossing, Innoko River, Dishna River, Iditarod River, Russian Mountains, and Kilbuck Mountains.
Reported and defined in 1898 by Spurr (1900, p. 239), U.S. Geological Survey (USGS). The name was derived from the Kuskokwim River which flows through the range. Spurr (p. 70) applied the name "Tanana Hills" to the low mountains at the northeast end of what are now the Kuskokwim Mountains. See Kuskokwim Bay.